Variants in FTO (fat-mass and obesity-associated), GLP1R (the receptor every GLP-1 compound targets), MC4R (a melanocortin receptor tied to satiety), and TCF7L2 (a transcription factor linked to glucose handling) describe the terrain a clinician prescribes into
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Zhou S, Zhang Y, Wang T et al (2021) Canagliflozin could improve the levels of renal oxygenation in newly diagnosed type 2 diabetes patients with normal renal function
When we If its not clinically appropriate, if side effects outweigh benefits, or if your goals can be met without medication, we wont recommend it