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Lower cagrilintide doses in combinations When combining, can reduce cagrilintide: 1.8mg cagrilintide + 2.4mg semaglutide: Still very effective (14-18% weight loss estimated) Better tolerated than both at 2.4mg Cost savings on cagrilintide Consider if GI-sensitive 1.2mg cagrilintide + 2.4mg semaglutide: Modest benefit from cagrilintide addition Minimal GI side effects from cagrilintide Semaglutide does heavy lifting May still achieve 12-15% total weight loss Testing approach: Start with standard doses (both 2.4mg) If intolerable, reduce cagrilintide first Maintain semaglutide at 2.4mg (well-tolerated, established) Find optimal cagrilintide dose for your tolerance Maintenance dosing after weight loss Strategies to sustain results long-term

For patients managing insulin resistance, obesity, PMOS, perimenopause, or related conditions with physician-prescribed peptide therapy, these accounts can meaningfully reduce the real cost of treatment by your full marginal tax rate, immediately

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doi: 10.1016/j.aggp.2025.100185 118 TabernaM.Gil MoncayoF.Jan-SalasE.AntonioM.ArribasL.VilajosanaE.et al