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The FDA continues to explain GLP-1 drugs should not be used in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2). Today, experts agree that there is no real risk of thyroid cancer associated with GLP-1 drugs

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In fact, several medical societies have issued statements advising against using compounded GLP-1 drugs outside of very specific shortage-related circumstances

It is unclear why directionality would vary between studies, although we note these studies were performed in specific disease contexts, and are in substantially smaller samples