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Even when a molecular diagnosis is in hand, determining the role a particular gene plays in the brain and assessing whether dietary treatment is appropriate is a daunting task

It also warns that combining the two agents increases the overall side effect burden and requires close monitoring

Thyroid 2008;18:1414.ArticlePubMed 2

In another context, when abundant CpG sites are present in the gene body, methylation of those nucleotides could lead to gene silencing by blocking transcription