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7 Hepatic (Liver) Insulin Resistance [caption id="attachment_8800" align="alignright" width="313"] Figure 2

240 FoxA2 is an upstream regulator of pancreatic duodenal homeobox 1 (pdx1) that is essential for pancreatic development and glucose homeostasis

However, not all patients require or tolerate this maximum dose

This precision approach emphasizes optimizing existing, well-studied monotherapy protocols rather than attempting combination regimens that lack clinical support and carry unquantified safety risks