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With respect to the wider GLP-1 drug class, the UK SmPCs for semaglutide (available on the electronic Medicines Compendium, emc) and tirzepatide (Mounjaro SmPC, emc) document GI adverse effects including nausea, vomiting, diarrhoea, constipation, and dyspepsia as well-characterised class effects

doi: 10.1152/ajpregu.00153.2008 111 NakataniYKawabeAMatsumuraMAsoYYasuTBanbaNet al

Going from 4mg to 8mg represents a doubling, and the GI adjustment can be rougher than earlier increases

Key Takeaway Traditional bulking typically results in a 1:1 or even 1:2 ratio of muscle to fat gain, meaning for every pound of muscle built, lifters often accumulate one to two pounds of fat