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In hypertensive states, mitochondria generate excessive ROS due to electron transport chain (ETC) disruption, particularly at complexes I and III, coupled with reduced antioxidant defenses (e.g., Mn-SOD) (Tbara et al., 2025)
The durability of results after discontinuation remains unproven in humans
Root topography by scanning electron micrography Fresh root segments (1 cm) from each treatment were fixed with 1 M PBS (pH 7.3) containing 2.5% (w/v) glutaraldehyde for 1 day
The adverse reactions included both temporary exacerbations similar to the "Jarisch Herxheimer reaction" and non-Herxheimer reactions
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