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However, the authors emphasize that it is difficult to determine precisely what proportion of the effect results from direct anti-inflammatory action and what proportion results from weight reduction and improved metabolic control

Inability to eat normally whilst taking other diabetes medications (particularly insulin or sulphonylureas) can lead to hypoglycaemia

Some GI adjustment (mild nausea, fullness) is normal and passes within 2-4 weeks

Reports in the UK highlight that Retatrutide still in clinical trials is being offered on Telegram, WhatsApp and via influencers on platforms such as TikTok for next-gen fat jabs