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doi: 10.3390/ijms25063154 66 MazokopakisEEKotsirisDA

As a general rule, most unopened insulin pens should be refrigerated between 2C and 8C (36F and 46F) and may be used until the printed expiration date when continuously stored under the manufacturers approved conditions

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However, the individual evidence for each compound is so robust, and the mechanisms so complementary, that the case for combining them is strong