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In SLE, mitochondrial dysfunction contributes to oxidative stress, altered apoptosis, mtDNA mutations, and impaired immune complex clearance, aggravating the loss of self-tolerance

This usually resolves within a day

Indian J Exp Biol 40:12404, PMID:13677625 Morris G, Maes M (2013) Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

The authors conclude that this antioxidant-based support is well tolerated and may provide clinically meaningful benefits, although controlled trials are needed to confirm efficacy (Cucinotta et al., 2022)