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Here, we sought to address this knowledge gap by modelling the trafficking and signalling behaviours of GLP-1R phospho-site null mutants in pancreatic -cells, uncovering the C-terminal Ser451/452 doublet as critical for the recruitment of GRK2 to the receptor, and revealing an unexpected positive correlation between GLP-1R phosphorylation and -cell cAMP production following receptor activation by its natural ligand, GLP-1

Functional selectivity and classical concepts of quantitative pharmacology

Talk to a healthcare provider about whether prescription GLP-1 medications are appropriate for your situation

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