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A global reference

The expression of proteins filaggrin (FLG) and loricrin (LOR) was evaluated by immunofluorescence, while the expression of mRNAs FLG and LOR in the skin was measured via qRT-PCR

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Conclusions The antagonistic pleiotropy in the function of the insulin/IGF-1 pathway reveals a paradox of the aging process since insulin/IGF-1 signaling is an important signaling pathway of growth and differentiation during development but its function accelerates the aging process later in the lifespan