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However, despite robust effects 35,36 , a large proportion, ~4050% of patients with SAD, has been reported to be either treatment resistant or not responding sufficiently to current treatments 37

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For example, it can significantly suppress the growth of P.g and its adhesion to host cells, while upregulating the expression of the antimicrobial peptide human -defensin-3 (HBD-3), thereby strengthening epithelial barrier function and enhancing mucosal immune defense (De Filippis et al., 2017)