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Absorption only works when conditions are right

The study then confirmed that depleting gut bacteria via antibiotics or germ-free mouse models essentially abolishes postprandial GLP-1, while fecal microbiota transplantation (FMT) restores it

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology [J]

In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials