Conversely, low-dose GLP-1 therapy is not appropriate for patients without established indications, particularly those seeking anti-inflammatory effects alone without diabetes or obesity
These drugs also slow down gastric emptying, which helps you feel fuller for longer.12 They also act on your brain chemistry to influence feelings of satiety, reducing the potential for a hormonal imbalance signaling that youre hungry when you arent.13 These various mechanisms of action work together to create a situation that makes it easier to lose weight by reducing your caloric intake and improving your insulin response
Different macronutrients stimulate GLP-1 secretion to varying degrees: Fiber and complex carbohydrates : Dietary fiber, particularly soluble fiber, enhances GLP-1 secretion by slowing nutrient absorption and allowing more prolonged contact with L-cells in the distal intestine
Most human studies rely on small sample sizes, short intervention periods, and subjective appetite or liking scales, while lacking objective gustatory measures such as taste-threshold testing or electrogustometry (153, 173, 180, 181)
