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20 These adaptive mechanisms are partly driven by increased osteoclast activity following unloading, 21 as observed after weight loss

This triggers synaptogenesis, the creation of new functional connections between neurons

The CPSDA, SCAN, NCAA Sport Science Institute, and ISSN agree that 3-6 mg/kg body mass of caffeine can improve exercise performance while 6-9 mg/kg can lead to overstimulation and other negative side-effects