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When GH is released in timed pulses rather than maintained at steady-state levels, it produces meaningfully different metabolic effects including better fat oxidation and a more favourable interaction with insulin sensitivity than continuous elevation does

Tesamorelin + Ipamorelin is the most clinically supported peptide stack for fat loss, backed by Phase 3 EGRIFTA trial data demonstrating 15-18% visceral adipose tissue reduction at 26 weeks alongside approximately 1.42 kg of lean mass preservation

14,38,39 Several therapies currently in clinical development target glucagon receptors in addition to incretin receptors due to the effects of glucagon on reducing food intake and increasing energy expenditure

When estrogen declines, all of these tissues are affected at once