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(2010) utilized IGF-1 and its analogs to investigate the relative contributions of PI3K/Akt versus MAPK/ERK signaling in IGF-1R-mediated cellular responses, demonstrating context-dependent pathway utilization across different cell types

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To analyze transcriptomic data, the researchers used Gene Set Variation Analysis (GSVA), a computational method that evaluates variation in pathway activity across samples within an expression dataset

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