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Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis

Accessed January 14, 2025.

Patients with a history of gastrointestinal issues including gastritis, acid reflux treated with PPIs, or any condition affecting stomach lining integrity already have compromised B12 absorption pathways

One of MOTS-C's downstream effects is increasing intracellular NAD+ utilization the mitochondria are running harder, so they're consuming more of the NAD+ pool