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Copper is beneficial in small amounts, but excessive copper signaling may increase inflammation or interfere with other active ingredients

321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury

Quantitative and qualitative variables were reported as mean standard deviation (SD) and number (percentage), respectively