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BPC-157 also exerts anti-inflammatory and antioxidative effects by regulating nitric oxide production, reducing cytokine activity (including TNF- and IL-6), and protecting endothelial function

However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)