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Data availability Computer code for LSA, parameter estimation, numerical simulations, and GSA with PRCC was implemented in and run with the programming and computation software MATLAB (MathWorks Inc., Natick, MA, USA)

Para uso de laboratorio se reconstituye con agua bacteriosttica: transfiere el diluyente con una jeringa estril, dirigiendo el chorro hacia la pared interna del vial y dejando que resbale lentamente

In instances, where assumptions of normality were not met, the non-parametric MannWhitney U test was used and reflected in the text

Endoscopy This involves inserting a thin, flexible tube through the mouth and down into the small intestine