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Causes Genetic predisposition (notably among South Asians) Lifestyle factors: overeating, sedentary habits, high-calorie diets, urbanization Obesity and central adiposity leading to insulin resistance Progressive -cell dysfunction Existing Treatments and Their Effectiveness The management of diabetes primarily involves: Lifestyle Changes: Including diet modification and exercise

Neuropharmacology 104:417 Cai S, Xu Y, Cooper RJ, Ferkowicz MJ, Hartwell JR, Pollok KE, Kelley MR (2005) Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents

Piovani D, Danese S, Peyrin-Biroulet L, Nikolopoulos GK, Lytras T, Bonovas S

On the flip side: some people even use glutathione supplements before drinking to prevent hangovers