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The cycle is completed when the keto intermediate is cleaved between C2 and C3 by thiolysis by a 3-ketoacyl-CoA thiolase with acetyl-CoA and the CoA ester of a fatty acid two carbons shorter than the original as the products

This releases free thiols, which have better antioxidant activity and enhance the GSH synthesis, besides reduced proteins, which have an important direct antioxidant activity in numerous cases, as for mercaptoalbumin

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