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GLP-1RAs reduce the expression of these molecules in vitro and in vivo

The combination addresses both limitations simultaneously

Expression of Akt1/2 , Irs1/2 and Insr , as well as several transcription factors important in adipocyte metabolism and function such as Pparg , Foxo1 , Cebpb and Tcf7l2 were reduced in adipose Ndufs2 KO mice

7 Along with antioxidant enzymes (glutathione S-transferases), Phase II detoxification protects cells from carcinogens and reactive oxygen species (ROS) via the Nrf2 pathway