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The effective mRNA treatments should accurately target specific cells, tissues, or organs, rendering transport efficiency, tissue bioavailability, half-life in bloodstream, and LNP performance significant limiting factors, particularly beyond the liver, which is more readily targeted

WG, LC, and LM critically revised this review

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Drug-Induced Alterations to Carnitine Metabolism Adverse drug reactions (ADRs) are defined by the World Health Organization (WHO) as a response to a drug that is unintended and occurs at doses normally used in man for the prophylaxis, diagnosis or therapy of disease, or for modification of physiological function [79]