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GLP-1 Receptor Agonists: Semaglutide, Tirzepatide, Retatrutide, and Survodutide Glucagon-like peptide-1 (GLP-1) receptor agonists enhance insulin secretion, suppress appetite, and delay gastric emptying, leading to reduced calorie intake and weight loss

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From the experimental results of example 1 and comparative examples 1 and 2, it can be seen that: the invention takes 7 th-8 th amino acid of a Cagrilintide sequence as pseudo-pro dipeptide Fmoc-Ala-Thr (pro-me-me) -OH, takes 10 th-11 th amino acid of the Cagrilintide sequence as pseudo-pro dipeptide Fmoc-Ala-Thr (pro-me-me) -OH, takes 21 st-22 th amino acid of the Cagrilintide sequence as pseudo-pro dipeptide Fmoc-Ser-Ser (pro-me-me) -OH, and has synergistic effect on improving the purity and yield of Cagrilintide

For more detailed information on metformins side effects and usage, you can refer to the Metformin patient information leaflet