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As anticipated, the data in Figure 25 demonstrate that both D-Nle-Cys-Ile-NH-(CH 2 ) 5 -CONH 2 and D-Nle-Tyr-He-NH-(CH 2 )s-CONH 2 , which bind HGF with high affinity (Figure 23) and effectively block its dimerization (Figure 24) were able to block Met auto-phosphorylation

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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner