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Concerns have been raised about the safety of hydroquinone in Europe, Japan, and the USA due to: Other reported cutaneous adverse effects of hydroquinone include: The safety of topical hydroquinone has not been established in pregnancy and lactation

The acute effect of different NAD+ precursors included in the combined metabolic activators. Free Radical Biology and Medicine (2023)

Safety and Efficacy of Glutathione in Dermatology