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The injections of actives were made with a 0.30 X 13mm (30G) needle applied at a depth of 4 to 6 mm at an angle of 45, aiming at delivering the substances in the subcutaneous layer

A 2025 orthopaedic sports medicine systematic review describes increasing use despite lack of FDA approval and bans in sport, and emphasizes that the evidence base is dominated by preclinical studies with limited high-quality human data

Compounded formulations are subject to the same quality standards and regulatory oversight, making them therapeutically equivalent while often providing cost savings through direct-to-patient pricing

Availability is subject to regulatory approval