doi: 10.1097/MD.0000000000006370
Normally, the excess of ROS in the mitochondria is neutralized by the endogenous antioxidant system which comprises several enzymes and non-enzymatic antioxidants [100] including reduced glutathione (GSH), vitamins C, and E, the Cu/Zn-superoxide dismutase (SOD) in the cytoplasm, and Mn-SOD in the mitochondrial matrix, catalase in the peroxisomes, glutathione peroxidase (GSH-Px), etc
Ren Q, Han X, Tang Y, Zhang X, Zou X, Cai X et al
10 Beyond economic endpoints, the model also showed clinically meaningful population health benefits, including reductions of 23.678 person-years per 100 patients of prediabetes and 25.963 person-years of T2D per 100 patient, along with additional reductions in several obesity-related comorbidities in the non-T2D population