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Behavioral intervention involved counseling by a dietitian or equivalent healthcare professional every 4 weeks through in-person visits or telephone sessions, focusing on adhering to a reduced-calorie diet (500 kcal deficit per day compared to estimated energy expenditure at randomization) and increased physical activity (encouraging 150 minutes per week, such as walking), with daily recording (via diary, app, or other tools) reviewed during counseling sessions

Interest in Zepbound self-pay and off-label applications like Zepbound for sleep apnea highlights both cost concerns and exploratory uses

Adults with a body mass index (BMI) of 30

Tapering windows are described as reducing rebound severity compared with sudden stops