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Additionally, comparative analyses of directed differentiation protocols derived from multiple groups have shown that they generate transcriptionally similar SC-islets (218)

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Key areas of investigation include modulation of the nitric oxide (NO) system through interaction with NOS isoforms, upregulation of growth factor receptors (including VEGFR2 and EGF receptor systems), and engagement of the FAK-paxillin signaling cascade associated with cell migration and adhesion