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Apart from aeroallergens and foods, microbial allergens ( Staphylococcus aureus, Pityrosporum ovale ) might play a role

2.2 Methods 2.2.1 Study procedure After an overnight fast of 10 hours at weeks 0 and 12, fasting blood samples were collected for baseline hematological and biochemical assessments

Similar caution applies to more recent short-term combination studies reporting improvements in ovulation, endocrine markers, or related reproductive parameters, because endpoint definitions, denominators, concomitant therapies, and follow-up windows varied across trials (103, 104)

Potential for resistance or adaptation Whether the body adapts to NNMT inhibition over time is unknown