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Immune cells then enter the vessel wall, leading to increased inflammatory signaling and the accumulation of foam cells

J Pineal Res 2009

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Fibrosis In myocardial ischemiareperfusion injury, DAMPs can induce cardiac fibroblast proliferation through activation of NLRP3 inflammasome, while releasing pro-inflammatory molecules such as IL-1, IL-6, and TNFa, which in turn exacerbate interstitial fibrosis [266, 272]