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For example, in one large study, about 70% of men with erectile dysfunction who took Viagra were able to get and maintain an erection compared to 22% who took a placebo

Its best viewed as part of a bigger plan that includes diet, exercise, and, if necessary, cholesterol medications like statins

One major limitation is the incomplete knowledge of the metabolic pathways and transformations that polyphenols undergo after ingestion, particularly due to interactions with the gut microbiome and the formation of diverse metabolites whose biological activities are not well characterized (120)