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10.1006/nbdi.2001.0412 237 SultanaO
With normalisation of glycated haemoglobin levels and weight losses around 1525%, therapeutic goals that were previously unrealistic are now within reach, and clinical trials have documented that these effects are associated with reduced risk of cardiovascular events and premature mortality
20 Primarily, NADPH provides reducing equivalents for fatty acid synthase (FASN), the main rate-limiting enzyme, to synthesize fatty acids with acetyl-CoA serving as a primer and malonyl-CoA as a two-carbon donor, 21,22 and provides the needed electrons for ironsulfur (Fe/S) protein assembly that participate in non-essential amino acid biosynthesis and lipoic acid synthesis, tRNA modification, DNA replication and repair, and telomere maintenance
Neither approach is foolproof, which is why knowing your own triggers matters
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