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Instead, the researchers found that one of its metabolic breakdown productsthe smaller fragment Ac-LKKTEwas responsible for the biological activity, suggesting that the entire pharmacological understanding of how TB-500 operates may be flawed or incomplete

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The accumulation is accompanied by the phosphorylation of S oligomers at Ser-129 that triggers apoptosis via rapid retraction of microtubules from the cellular process (Kragh et al., 2009)

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