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Studies in experimental animals have demonstrated that both substances affect the brains serotonergic and dopaminergic pathways, with MDMA primarily targeting the serotonin (5-HT) transporter and dopamine (DA) transporter, stimulating the efflux of these neurotransmitters from presynaptic vesicles Cardiovascular Stress MDMA and MDA increase heart rate and blood pressure, which can be dangerous for individuals with underlying heart conditions
In some cases, this could lead to palpitations
10.1371/journal.pone.0073989 PLoS One 70 ZhangL
Every one kilogram reduction in body weight is associated with a decrease in bone mineral density of 0.1% at the femoral neck [50]
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