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The questions that Phase 3 will need to answer and that regulators will scrutinize closely include cardiovascular outcomes over extended periods, liver function changes beyond the 48-week window, potential interactions with other metabolic agents, and safety in populations not well-represented in Phase 2

The interaction between semaglutide and alcohol is another practical concern, as many users report increased alcohol sensitivity and reduced tolerance while on GLP-1 agonists

The announcement also came less than two weeks after Democratic Gov

B12 inclusion addresses the nutritional component of fatigue but does not fully prevent the physiological adaptation period