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Cleavage of Boc groups with 4 M HCl/dioxane followed by a coupling reaction with the -carboxyl group of the N -hydroxysuccinimide active ester of Boc-Glu--OtBu resulted in the corresponding glutathione disulfide-1,1- 13 C with fully protected N and C-terminals

Furthermore, this antioxidant duo has been found to play a vital role in the immune system , protecting the body against free radicals and oxidants

And it retains the full anti-inflammatory activity of the parent hormone without the broader melanogenic and hormonal effects

Analysis of expression levels of three mitochondrial proteins known to combat oxidative stress revealed that peroxiredoxin-5 (PRDX5) and superoxide dismutase 2 (SOD2), but not glutathione disulphide reductase, were significantly decreased in patient samples compared with those in fertile-donor samples