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Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

reported outcomes are more plausibly indirect via recovery, routine adherence, and activity changes

A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig