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Mass Spectrometry Applications Mass spectrometry enables: N-terminal truncation identification C-terminal truncation analysis Relative impurity quantification Structural confirmation of shortened variants Why Truncation Monitoring Matters These variants can potentially affect: Product potency Stability Pharmacokinetics Regulatory comparability assessments As a result, truncation products must be carefully monitored throughout biosimilar development

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53 Moreover, there was a linear relationship between HRQoL and BMI

The design of these compounds mainly involves the replacement of the metal ion with rhodium, nickel, or zinc, or may have an inactive ligand attached, such as 4-ethylphenyl