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Ipamorelin's defining tolerability feature is selectivity: in its foundational pharmacology it stimulated growth-hormone release without meaningfully raising cortisol, prolactin, or ACTH, and without the appetite stimulation seen with other growth-hormone-releasing peptides avoiding several of their characteristic side effects

However, in a double-blind, placebo-controlled trial in 32 healthy adults, propionyl-L-carnitine (1 g/day or 3 g/day) for eight weeks did not improve aerobic or anaerobic exercise performance (130)

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IGF DES 1,3 activates satellite cells which are essential for muscle repair, hypertrophy and generation of new muscle fibers