10B, C), suggesting that complete deletion, rather than conservative substitution, is required to disrupt the interface
Appears as a flat lesion with an irregular shape Shows uneven coloration, often with varying shades of brown or black Commonly found on areas with long-term sun exposure Can resemble benign lesions such as freckles or age spots, making recognition more difficult Biological behavior Begins as lentigo maligna, a slow-growing, in situ (non-invasive) phase May eventually progress into lentigo maligna melanoma, where it becomes invasive Once invasive, it has the potential to spread to other parts of the body Importance Because lentigo maligna melanoma can closely resemble harmless skin markings, early detection can be challenging but is critical
Some changes, such as improved appetite control, often begin within the first few weeks
A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation