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[2]Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study, PMID: 39002641.

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GLP-1RAs inhibit RGC apoptosis in glaucoma through GABAergic signaling, but their role in AMD, characterized by oxidative stress and choroidal neovascularization, needs further investigation ( The latest diabetic retinopathy preferred practice guidelines from the American Academy of Ophthalmology indicate that the rising use of GLP-1RAs may lead to quick glycemic control and severe hypoglycemia and has been reported to cause higher rates of retinopathy complications, especially in patients with early-stage DR ( 4.2 Delivery optimization Systemic administration of GLP-1RAs reduces their availability in the retina and can lead to off-target effects, particularly gastrointestinal issues

Its important to wait at least 14 days after stopping an MAOI before starting sertraline