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A Review and Meta-Analysis of the Safety and Efficacy of Using Glucagon-like Peptide-1 Receptor Agonists

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Black Box Warning GLP-1 receptor agonists, including semaglutide, carry a black box warning for the risk of thyroid C-cell tumors, based on findings in animal studies

3) Some believe these drugs will not see widespread adoption because they are most effective subcutaneously (administered via an autoinjector as pictured here): While a certain subset will always have a phobia of needles, its worth considering the lengths that people have gone to in the past to lose weight (taking pills with tapeworms in them, for example)