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Important outcomes that the clinical expert considers clinically meaningful for their patients include the following: improved survival improved hemoglobin A1C by at least 0.5% improved blood pressure improvement/normalization of liver enzymes improvement in lipid profile (reduced triglycerides and low-density lipoprotein, in particular) the patient reporting reduced hunger or reduced food cravings and feeling more in control of their food intake reduced risk of weight-related cancers (e.g., endometrial, breast) the patient reporting improved mobility or ability to perform daily activities the resolution of prediabetes with glucose parameters returning to the normal range a total body weight loss of 5% or greater a plateau in weight regain or reversal of weight regain in a patient who has undergone bariatric surgery