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Emotional blunting and reduced motivation are increasingly reported in clinical literature, though they are not yet listed as official side effects by drug manufacturers

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3 Neuromodulatory effects of cannabinoids 3.1 Endocannabinoid signaling in the aging brain The molecular architecture of the ECS is defined by the presence of the CB1R and CB2R, together with their endogenous ligands, most notably AEA and 2-AG (Haspula and Clark, 2020)