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Genes associated with the cell cycle, including cyclin-dependent kinase 1 ( Cdk1 ) and BUB1 mitotic checkpoint serine/threonine kinase ( Bub1 ), showed increased expression across the trajectory

Given these results, it is important to consider the time point of therapeutic administration, as earlier intervention may yield greater treatment efficacy, as evidenced by the age-dependent success in the mouse studies

If you have been taking metformin but your blood sugar levels are still uncontrolled, or you want additional benefits such as weight reduction, cardiovascular risk reduction, or kidney protection, semaglutide alone or as a combination therapy with metformin is suitable for you